Short Mitochondrial ARF Triggers Parkin/PINK1-dependent Mitophagy*
Identifieur interne : 000929 ( Main/Exploration ); précédent : 000928; suivant : 000930Short Mitochondrial ARF Triggers Parkin/PINK1-dependent Mitophagy*
Auteurs : Karl Grenier [Canada] ; Maria Kontogiannea [Canada] ; Edward A. Fon [Canada]Source :
- The Journal of Biological Chemistry [ 0021-9258 ] ; 2014.
English descriptors
- KwdEn :
- Animals, Cyclin-Dependent Kinase Inhibitor p16 (metabolism), Enzyme Stability, HEK293 Cells, HeLa Cells, Humans, Membrane Potential, Mitochondrial, Mice, Mitochondria (metabolism), Mitochondrial Degradation, Neurons (metabolism), Protein Kinases (metabolism), Protein Transport, Rats, Ubiquitin-Protein Ligases (metabolism).
- MESH :
- chemical , metabolism : Cyclin-Dependent Kinase Inhibitor p16, Protein Kinases, Ubiquitin-Protein Ligases.
- metabolism : Mitochondria, Neurons.
- Animals, Enzyme Stability, HEK293 Cells, HeLa Cells, Humans, Membrane Potential, Mitochondrial, Mice, Mitochondrial Degradation, Protein Transport, Rats.
Abstract
Url:
DOI: 10.1074/jbc.M114.607150
PubMed: 25217637
PubMed Central: 4207970
Affiliations:
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Le document en format XML
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Fon</name><affiliation wicri:level="4"><nlm:aff id="aff1">From the Department of Neurology and Neurosurgery and McGill Parkinson Program, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>From the Department of Neurology and Neurosurgery and McGill Parkinson Program, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25217637</idno><idno type="pmc">4207970</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207970</idno><idno type="RBID">PMC:4207970</idno><idno type="doi">10.1074/jbc.M114.607150</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000577</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000577</idno><idno type="wicri:Area/Pmc/Curation">000577</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000577</idno><idno type="wicri:Area/Pmc/Checkpoint">000410</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000410</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000660</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000660</idno><idno type="wicri:Area/PubMed/Curation">000660</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000660</idno><idno type="wicri:Area/PubMed/Checkpoint">000660</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000660</idno><idno type="wicri:Area/Ncbi/Merge">001905</idno><idno type="wicri:Area/Ncbi/Curation">001905</idno><idno type="wicri:Area/Ncbi/Checkpoint">001905</idno><idno type="wicri:doubleKey">0021-9258:2014:Grenier K:short:mitochondrial:arf</idno><idno type="wicri:Area/Main/Merge">000931</idno><idno type="wicri:Area/Main/Curation">000929</idno><idno type="wicri:Area/Main/Exploration">000929</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Short Mitochondrial ARF Triggers Parkin/PINK1-dependent Mitophagy<xref ref-type="fn" rid="FN1">*</xref></title><author><name sortKey="Grenier, Karl" sort="Grenier, Karl" uniqKey="Grenier K" first="Karl" last="Grenier">Karl Grenier</name><affiliation wicri:level="4"><nlm:aff id="aff1">From the Department of Neurology and Neurosurgery and McGill Parkinson Program, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>From the Department of Neurology and Neurosurgery and McGill Parkinson Program, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Kontogiannea, Maria" sort="Kontogiannea, Maria" uniqKey="Kontogiannea M" first="Maria" last="Kontogiannea">Maria Kontogiannea</name><affiliation wicri:level="4"><nlm:aff id="aff1">From the Department of Neurology and Neurosurgery and McGill Parkinson Program, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>From the Department of Neurology and Neurosurgery and McGill Parkinson Program, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Fon, Edward A" sort="Fon, Edward A" uniqKey="Fon E" first="Edward A." last="Fon">Edward A. Fon</name><affiliation wicri:level="4"><nlm:aff id="aff1">From the Department of Neurology and Neurosurgery and McGill Parkinson Program, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>From the Department of Neurology and Neurosurgery and McGill Parkinson Program, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author></analytic><series><title level="j">The Journal of Biological Chemistry</title><idno type="ISSN">0021-9258</idno><idno type="eISSN">1083-351X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cyclin-Dependent Kinase Inhibitor p16 (metabolism)</term><term>Enzyme Stability</term><term>HEK293 Cells</term><term>HeLa Cells</term><term>Humans</term><term>Membrane Potential, Mitochondrial</term><term>Mice</term><term>Mitochondria (metabolism)</term><term>Mitochondrial Degradation</term><term>Neurons (metabolism)</term><term>Protein Kinases (metabolism)</term><term>Protein Transport</term><term>Rats</term><term>Ubiquitin-Protein Ligases (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cyclin-Dependent Kinase Inhibitor p16</term><term>Protein Kinases</term><term>Ubiquitin-Protein Ligases</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mitochondria</term><term>Neurons</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Enzyme Stability</term><term>HEK293 Cells</term><term>HeLa Cells</term><term>Humans</term><term>Membrane Potential, Mitochondrial</term><term>Mice</term><term>Mitochondrial Degradation</term><term>Protein Transport</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background:</bold> PINK1 and Parkin promote mitochondrial autophagy upon loss of mitochondrial membrane potential.</p><p><bold>Results:</bold> smARF induces Parkin/PINK1-mitochondrial autophagy in neurons.</p><p><bold>Conclusion:</bold> smARF is upstream of Parkin and PINK1 in mitochondrial autophagy.</p><p><bold>Significance:</bold> Parkin/PINK1-mitochondrial autophagy can be triggered by intrinsic signaling.</p></div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Grenier, Karl" sort="Grenier, Karl" uniqKey="Grenier K" first="Karl" last="Grenier">Karl Grenier</name></region><name sortKey="Fon, Edward A" sort="Fon, Edward A" uniqKey="Fon E" first="Edward A." last="Fon">Edward A. Fon</name><name sortKey="Kontogiannea, Maria" sort="Kontogiannea, Maria" uniqKey="Kontogiannea M" first="Maria" last="Kontogiannea">Maria Kontogiannea</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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